Target to Hit
Hit synthesis and binding affinity evaluation
Hit synthesis involves the production of linear, monocyclic, and bicyclic peptides,
each yielding 2 to 5 mg at 95% purity.
For affinity evaluation, Surface Plasmon Resonance (SPR) emerges as the preferred method. It offers a comprehensive assessment of association rate (Kon), dissociation rate (Koff), and equilibrium dissociation constant (KD) within a system characterized by fewer interfering factors, thus ensuring greater accuracy.
