In the human body, antibody generation begins with genetic rearrangement in B cells for diverse antibody production. Affinity maturation, occurring in lymphoid organs, enhances antibody specificity through somatic hypermutation and selection for higher antigen-binding affinity, improving immune response effectiveness.

Similarly, we offer antibody discovery service utilizing our mRNA display technology, with native scFv library amplified from naïve B cells donor. Additionally, we offer antibody maturation service. First we generate a mutagenesis library comprising a diverse array of variants via random or targeted mutagenesis of the CDR genotype. Subsequently, mRNA display efficiently identifies scFv variants with improved binding affinity. Mutations that boost antibody-antigen binding affinity are methodically pinpointed and integrated into the antibody sequence.