Hit to Lead
Preliminary SAR Expansion
Preliminary SAR analysis provides valuable insights into which structural modifications enhance or diminish the peptide's biological effects. This information guides the rational design of peptide analogs with improved pharmacological properties, laying the groundwork for further optimization and development of potential drug candidates. It includes Define Objectives, Design Peptide Variants, Synthesis, Characterization, Biological Assays, Data Analysis, Iterative Optimization, Validation.